TISSUE oxygen saturation in malnutrition and pneumonia
We are developing a non-invasive diagnostic and treatment-progress monitoring tool to assess peripheral muscle oxygen saturation using near-infrared spectroscopy (NIRS). The absorption of very specific wavelengths of light in the 660-940 nm range will provide an objective measure of a child’s metabolic status and allow identification of those who are at increased risk of dying from pneumonia. This tool will assess disease severity and monitor treatment progress. With ethics board approval and informed consent, we will collect NIRS data from 200 children under 5 years of age, in Uganda. We will measure muscle oxygen saturation on the anterior aspect of both arms at rest and changes in TOI following venous occlusion of the upper arm (recovery time constant). NIRS signals will be collected at a number of discrete wavelengths in the 660-940 nm range, using different emitter-detector distances in the range of 2-4 cm.